In her final year, graduate student Hanna Trzeciakiewicz wins two honorable and prestigious UNC awards. Hanna was selected to receive the 2020 Dean’s Distinguished Dissertation Award in the area of Biological and Life Sciences. She also received the 2020 Horizon Award!!
Dr. Cohen has been in the news a lot lately! Here’s him on another radio show, called Radio in Vivo! A great way to learn about Dr. Cohen’s inspiration and drive to enter Alzheimer’s disease research. Click the picture or here to check it out.
Dr. Todd Cohen was featured in “The News and Notes Podcast” by Jeffrey C. McAndrew, where they discussed new, promising discoveries in ALS and what a typical day is like in the Cohen Lab at UNC Chapel Hill.
Dr. Todd Cohen and the efforts of the Cohen Lab were mentioned in the Oshkosh Herald! The story below features the efforts of Gary Beyer, a patient with sporadic Inclusion Body Myositis (sIBM), a muscle weakening disease that is similar in molecular origin to Amyotropic Lateral Sclerosis (ALS).
The National Science Foundation predoctoral fellowships are designed to help ensure the vitality of the human resource base of science and engineering in the United States and reinforces its diversity. The program recognizes and supports outstanding graduate students in NSF-supported science, technology, engineering, and mathematics disciplines who are pursuing research-based master’s and doctoral degrees at accredited US institutions.
The Cohen Lab just published a new article, The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology in Cell Press, and the UNC School of Medicine Newsroom Interviewed Dr. Cohen on the article! A sneak peak:
Led by Todd Cohen, PhD, assistant professor of neurology, UNC scientists used human cell cultures to show how amyloid beta can trigger a dramatic inflammatory response in immune cells and how that interaction damages neurons. Then they showed how that kind of neuron damage leads to the formation of bead-like structures filled with abnormal tau protein. Similar bead-like structures are known to form in the brain cells of people with Alzheimer’s disease.
TDP-43 mediated neurodegeneration in Amyotrophic Lateral Sclerosis (ALS)
Like tau acetylation and phosphorylation in Alzheimer’s Disease, TDP-43 modifications similarly promote aberrant pathology seen in diseased brain and spinal cord of ALS and FTLD-TDP patients. Understanding such post-translational mechanisms could lead to better therapeutic avenues to pursue for ALS, FTD and other diseases characterized by TDP-43 pathology.