BETTER UNDERSTANDING THE MECHANISMS OF NEURODEGENERATIVE DISEASE

 

Baggio is a second-year Ph.D. student and NSF fellow in the Biochemistry and Biophysics program. Before coming to UNC for graduate studies, Baggio received a B.S. in Molecular and Microbiology at the University of Central Florida (UCF). There he studied epigenetic regulation of alpha-synuclein in Parkinson’s disease in the laboratory of Dr. Yoon-Seong Kim. From there, Baggio collaborated with Dr. Dmitri Kolpashchikov in the UCF Department of Chemistry where he designed a biosensor for pathological alpha-synuclein. After graduating in May 2017, Baggio joined the lab of Dr. Kenneth Teter where he investigated the biochemical properties of a molecular chaperone, Protein Disulfide Isomerase, and its ability to disaggregate alpha-synuclein and amyloid beta fibrils as a pan-therapeutic for neurodegenerative proteinopathies. Now in the Cohen lab, Baggio is investigating 1) a gene therapy strategy for eliminating ALS associated TDP-43 proteinopathy in vivo using Protein Disulfide Isomerase and 2) T-cell-mediated neuroinflammation in ALS.

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